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Targeting Interleukin-6 Signaling in Clinic

Targeting Interleukin-6 Signaling in Clinic

Sujin Kang, Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto

Immunity. 2019 Apr 16;50(4):1007-1023.

PMID: 30995492

Abstract:

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive synthesis of IL-6 and dysregulation of IL-6 receptor signaling is involved in disease pathology. Therapeutic agents targeting the IL-6 axis are effective in rheumatoid arthritis, and applications are being extended to other settings of acute and chronic inflammation. Recent studies reveal that selective blockade of different modes of IL-6 receptor signaling has different outcomes on disease pathology, suggesting novel strategies for therapeutic intervention. However, some inflammatory diseases do not seem to respond to IL-6 blockade. Here, we review the current state of IL-6-targeting approaches in the clinic and discuss how to apply the growing understanding of the immunobiology of IL-6 to clinical decisions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP206978145	6′,7′-Epoxybergamottin		206978-14-5	Price

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