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Temperature-sensitive Polyamidoamine dendrimer/poly(N-isopropylacrylamide) Hydrogels With Improved Responsive Properties

Temperature-sensitive Polyamidoamine dendrimer/poly(N-isopropylacrylamide) Hydrogels With Improved Responsive Properties

Jian-Tao Zhang, Shi-Wen Huang, Ren-Xi Zhuo

Macromol Biosci. 2004 Jun 25;4(6):575-8.

PMID: 15468250

Abstract:

Novel temperature-sensitive poly(N-isopropylacrylamide)/amine-terminated polyamidoamine dendrimer G6-NH2 hydrogels with fast responsive properties were synthesized by forming semi-interpenetrating polymeric networks. In contrast to the conventional PNIPA hydrogel, these new gels showed rapid shrinking rate at the temperature above lower critical solution temperature (LCST), and exhibited higher equilibrium swelling ratio at room temperature. All these properties might be attributed to the incorporation of polyamidoamine dendrimer G6-NH2, which forms water-releasing channels and increases the hydrophilicity of PNIPA network. The novel hydrogels have potential applications in drug and gene delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74674	Poly(N-isopropylacrylamide), amine terminated			Price
LS74682	Poly(N-isopropyl acrylamide), amine terminated			Price

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