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Terpinen-4-ol and Carvacrol Affect Multi-Species Biofilm Composition

Terpinen-4-ol and Carvacrol Affect Multi-Species Biofilm Composition

Patricia Milagros Maquera Huacho, Esteban Rodriguez Herrero, Tim Verspecht, Martine Pauwels, Elcio Marcantonio Jr, Denise Madalena Palomari Spolidorio, Wim Teughels

Biofouling. 2019 May;35(5):561-572.

PMID: 31282200

Abstract:

The aim of this study was to investigate the cytotoxic activity and inhibitory effect of terpinen-4-ol (T4ol) and carvacrol against single- and multi-species biofilms. The toxicity of each compound was tested on oral keratinocytes and evaluated by XTT assay. Inhibition and eradication of single-species biofilms were analyzed by crystal violet assay and the effect on multi-species biofilm composition was evaluated by qPCR. T4ol and carvacrol did not affect the epithelial cell viability, in contrast to chlorhexidine, which showed a high cytotoxic effect. Inhibition and eradication of single-species biofilms treated with T4ol and carvacrol were observed. The same inhibitory effect was observed for multi-species biofilms, especially on periodontal pathogens. In conclusion, specific concentrations of T4ol and carvacrol without toxicity towards the epithelial cells reduced the numbers of periodontal pathogens in single- and multi-species biofilms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2438100	(+)-Terpinen-4-ol		2438-10-0	Price
AP562743	Terpinen 4-ol		562-74-3	Price

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