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Tetrabutylammonium Bromide-Promoted Metal-Free, Efficient, Rapid, and Scalable Synthesis of N-Aryl Amines

Tetrabutylammonium Bromide-Promoted Metal-Free, Efficient, Rapid, and Scalable Synthesis of N-Aryl Amines

Chad R Johnson, Mohd Imran Ansari, Andrew Coop

ACS Omega. 2018 Sep 30;3(9):10886-10890.

PMID: 30288459

Abstract:

A rapid, transition metal-free, high-yielding, tetrabutylammonium bromide-promoted method of N-arylation is reported within. The optimized conditions tolerated a wide range of secondary amines and was equally effective with bromo- and chlorobenzene-including substituted aryl halides. The developed method is found to be effective for N-arylation when compared to earlier methods which involve harsh conditions, transition metals, lack of scalability, and long reaction times. Our method utilizes conventional heating only; it is readily scalable; and the products are facile to purify.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1643192	Tetrabutylammonium bromide		1643-19-2	Price

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