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Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK Inhibitor

Clement Opoku-Temeng, Neetu Dayal, Delmis E Hernandez, N Naganna, Herman O Sintim

Chem Commun (Camb). 2018 May 1;54(36):4521-4524.

PMID: 29629444

Abstract:

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP229878 Phenanthridine Phenanthridine 229-87-8 Price
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