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Tetrahydro-6-biopterin Is Associated With tetrahydro-7-biopterin in Primary Murine Mast Cells

Tetrahydro-6-biopterin Is Associated With tetrahydro-7-biopterin in Primary Murine Mast Cells

I Ziegler, L Hültner

FEBS Lett. 1992 Jul 28;307(2):147-50.

PMID: 1644167

Abstract:

Murine bone marrow-derived mast cells proliferate in response to interleukin 3. In addition to 6-biopterin, 7-biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6- and 7-carboxylic acids. 7-Biopterin comprised 31.9 (+/- 7.7)% of the total biopterin. It was absent in cells which were grown with of L-p-chlorophenylalanine, an inhibitor of tryptophan 5-mono-oxygenase. Both 6- and 7-biopterin were present in the cell as their tetrahydro forms. From these data we conclude that 7-biopterin, in contrast to e.g. brain tissue, regularly occurs as a normal metabolite in primary mast cells and that it is generated during hydroxylation of tryptophan.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP22150761	6-Biopterin		22150-76-1	Price

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