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Tetrahydrocurcumin Protects Against Spinal Cord Injury and Inhibits the Oxidative Stress Response by Regulating FOXO4 in Model Rats

Tetrahydrocurcumin Protects Against Spinal Cord Injury and Inhibits the Oxidative Stress Response by Regulating FOXO4 in Model Rats

Jiancheng Xi, Xiaobo Luo, Yipeng Wang, Jinglong Li, Lixin Guo, Guangseng Wu, Qingui Li

Exp Ther Med. 2019 Nov;18(5):3681-3687.

PMID: 31602247

Abstract:

It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti-metastasis, anticancer and anti-depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso-Beattie-Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase-3 activity and B-cell lymphoma 2-associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36062041	Tetrahydrocurcumin		36062-04-1	Price

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