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Tetrapropylammonium Perruthenate as a Mild and Efficient Oxidant for Sensitive Steroidal Alcohols

C K Acosta, P N Rao, H K Kim

Steroids. 1993 May;58(5):205-8.

PMID: 8356571

Abstract:

Tetrapropylammonium perruthenate N-methylmorpholine N-oxide oxidation of steroidal alcohols is described. The reagent combination is mild and gave good yields of the corresponding ketones. Although the oxidation can generate ketones from 3-, 11-, 15-, 17-, and 20-hydroxy steroids, the oxidation of homoallylic alcohols proceeds in low yields. Finally, we observed that the oxidation reagents will convert 17 alpha-hydroxy-20-keto steroids to 17-keto systems in excellent yield.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP114615826 Tetrapropylammonium perruthenate Tetrapropylammonium perruthenate 114615-82-6 Price
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