Home
Resources
Publications
The Analgesic and Anti-Inflammatory Profile of Ketorolac and Its Tromethamine Salt

The Analgesic and Anti-Inflammatory Profile of Ketorolac and Its Tromethamine Salt

W H Rooks 2nd, P J Maloney, L D Shott, M E Schuler, H Sevelius, A M Strosberg, L Tanenbaum, A J Tomolonis, M B Wallach, D Waterbury

Drugs Exp Clin Res. 1985;11(8):479-92.

PMID: 3879752

Abstract:

Ketorolac tromethamine[(+/-)-5(benzoyl)-2,3-dihydro-1N-pyrrolizine-1-carboxylic acid tris hydroxymethylaminomethane salt] is a highly potent member of a new class of compounds having analgesic and anti-inflammatory activity. When given orally in tests involving underlying inflammation it was a potent analgesic, whereas it was inactive in tests for narcotic activity. It was also highly active orally in rat models of acute and chronic inflammation and pyresis. These properties are mediated primarily via the compound's potent prostaglandin cyclooxygenase inhibitory activity. The agent elicited mild CNS and cardiovascular activity only at doses far in excess of those required for analgesic and anti-inflammatory activity. A single 10 mg tablet given orally to human volunteers following surgery provided pain relief equivalent to that provided by 10 mg of morphine given intramuscularly. When given intramuscularly to rabbits (0.25 ml of a 0.31-5% solution) or man (3 ml of a 1-3% solution), no drug-related irritation or changes in creatine phosphokinase were seen. Solutions (less than or equal to 0.5%) applied to the eyes of animals and man were not irritating. When applied topically in rat and rabbit models of ocular inflammation, less than or equal to 0.5% solutions of ketorolac tromethamine inhibited the inflammatory response.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP167105808	Ketorolac Related Compound A		167105-80-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: