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The Angular Structure of ONC201, a TRAIL Pathway-Inducing Compound, Determines Its Potent Anti-Cancer Activity

The Angular Structure of ONC201, a TRAIL Pathway-Inducing Compound, Determines Its Potent Anti-Cancer Activity

Jessica Wagner, Christina Leah Kline, Richard S Pottorf, Bhaskara Rao Nallaganchu, Gary L Olson, David T Dicker, Joshua E Allen, Wafik S El-Deiry

Oncotarget. 2014 Dec 30;5(24):12728-37.

PMID: 25587031

Abstract:

We previously identified TRAIL-inducing compound 10 (TIC10), also known as NSC350625 or ONC201, from a NCI chemical library screen as a small molecule that has potent anti-tumor efficacy and a benign safety profile in preclinical cancer models. The chemical structure that was originally published by Stahle, et. al. in the patent literature was described as an imidazo[1,2-a]pyrido[4,3-d]pyrimidine derivative. The NCI and others generally accepted this as the correct structure, which was consistent with the mass spectrometry analysis outlined in the publication by Allen et. al. that first reported the molecule's anticancer properties. A recent publication demonstrated that the chemical structure of ONC201 material from the NCI is an angular [3,4-e] isomer of the originally disclosed, linear [4,3-d] structure. Here we confirm by NMR and X-ray structural analysis of the dihydrochloride salt form that the ONC201 material produced by Oncoceutics is the angular [3,4-e] structure and not the linear structure originally depicted in the patent literature and by the NCI. Similarly, in accordance with our biological evaluation, the previously disclosed anti-cancer activity is associated with the angular structure and not the linear isomer. Together these studies confirm that ONC201, produced by Oncoceutics or obtained from the NCI, possesses an angular [3,4-e] structure that represents the highly active anti-cancer compound utilized in prior preclinical studies and now entering clinical trials in advanced cancers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4245297	TIC10 angular			Price

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