Home
Resources
Publications
The Anticonvulsant Sulfamide JNJ-26990990 and Its S,S-dioxide Analog Strongly Inhibit Carbonic Anhydrases: Solution and X-ray Crystallographic Studies

The Anticonvulsant Sulfamide JNJ-26990990 and Its S,S-dioxide Analog Strongly Inhibit Carbonic Anhydrases: Solution and X-ray Crystallographic Studies

Anna Di Fiore, Giuseppina De Simone, Vincenzo Alterio, Vincenzo Riccio, Jean-Yves Winum, Fabrizio Carta, Claudiu T Supuran

Org Biomol Chem. 2016 Jun 7;14(21):4853-8.

PMID: 27151329

Abstract:

JNJ-26990990 ((benzo[b]thien-3-yl)methyl)sulfamide, a sulfamide derivative structurally related to the antiepileptic drug zonisamide, was reported to be devoid of carbonic anhydrase (CA, EC 4.2.1.1) inhibitory properties. Here we report that JNJ-26990990 and its S,S-dioxide analog significantly inhibit six human (h) isoforms, hCA I, II, VII, IX, XII and XIV, involved in crucial physiological processes. Inhibition and X-ray crystallographic data for the binding of the two compounds to these enzymes show significant similarity with the zonisamide inhibitory pattern. These findings prompted us to reconsider the structural/pharmacological requirements for designing effective antiepileptics possessing zinc-binding groups of the sulfamide, sulfamate or sulfonamide type in their molecules.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68291974-A	Zonisamide solution		68291-97-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: