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The Antidepressant-Like Effect of Bacopaside I: Possible Involvement of the Oxidative Stress System and the Noradrenergic System

The Antidepressant-Like Effect of Bacopaside I: Possible Involvement of the Oxidative Stress System and the Noradrenergic System

Xiaojun Liu, Fang Liu, Rongcai Yue, Yuanyuan Li, Jigang Zhang, Shuping Wang, Shoude Zhang, Rui Wang, Lei Shan, Weidong Zhang

Pharmacol Biochem Behav. 2013 Sep;110:224-30.

PMID: 23872136

Abstract:

In the present study, the antidepressant-like effect of bacopaside I, a saponin compound present in the Bacopa monniera plant, was evaluated by behavioral and neurochemical methods. Bacopaside I (50, 15 and 5 mg/kg) was given to mice via oral gavage for 7 successive days. The treatment significantly decreased the immobility time in mouse models of despair tests, but it did not influence locomotor activity. Neurochemical assays suggested that treatment by bacopaside I (50, 15 and 5 mg/kg) improved brain antioxidant activity to varying degrees after the behavioral despair test. Bacopaside I (15 and 5 mg/kg) significantly reversed reserpine-induced depressive-like behaviors, including low temperature and ptosis. Conversely, bacopaside I did not affect either brain MAO-A or MAO-B activity after the behavioral despair test in mice. Additionally, 5-hydroxytryptophan (a precursor of 5-serotonin) was not involved in the antidepressant-like effect of bacopaside I. These findings indicated that the antidepressant-like effect of bacopaside I might be related to both antioxidant activation and noradrenergic activation, although the exact mechanism remains to be further elucidated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP382148472	Bacopaside I		382148-47-2	Price

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