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The Anxiolytic-Like Effects of Ginsenoside Rg2 on an Animal Model of PTSD

The Anxiolytic-Like Effects of Ginsenoside Rg2 on an Animal Model of PTSD

Zhuo-Wei Gao, Rong-Le Ju, Min Luo, Shu-Lian Wu, Wen-Tong Zhang

Psychiatry Res. 2019 Sep;279:130-137.

PMID: 31103345

Abstract:

Post traumatic stress disorder (PTSD) is one of the mental illness. The antidepressant-like properties of ginsenoside Rg2 (GRg2) have been shown, while little is known about its anti-PTSD-like effects. In the present study, the PTSD-associated behavioral deficits in rats were induced following exposure to single prolonged stress (SPS). The results showed that the decreased time and entries in the open arms in elevated plus maze test (EPMT) and increased freezing duration in contextual fear paradigm (CFP) were reversed by GRg2 (10 and 20 mg/kg) without affecting the locomotor activity. In addition, GRg2 (10 and 20 mg/kg) could block the decreased levels of progesterone, allopregnanolone, serotonin (5-HT), 5-Hydroxyindoleacetic acid (5-HIAA), corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH) in the brain or serum. In summary, GRg2 alleviated the PTSD-associated behavioral deficits with biosynthesis of neurosteroids, normalization of serotonergic system and HPA axis dysfunction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52286745	Ginsenoside Rg2		52286-74-5	Price

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