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The BAFF/APRIL System: Emerging Functions Beyond B Cell Biology and Autoimmunity

The BAFF/APRIL System: Emerging Functions Beyond B Cell Biology and Autoimmunity

Fabien B Vincent, Damien Saulep-Easton, William A Figgett, Kirsten A Fairfax, Fabienne Mackay

Cytokine Growth Factor Rev. 2013 Jun;24(3):203-15.

PMID: 23684423

Abstract:

The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414835	BAFF human			Price
IAR4248887	TACI human			Price

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