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The Bisindolylmaleimide GF 109203X, a Selective Inhibitor of Protein Kinase C, Does Not Inhibit the Potentiating Effect of Phorbol Ester on Ethanol-Induced Phospholipase C-mediated Hydrolysis of Phosphatidylethanolamine

Z Kiss, H Phillips, W H Anderson

Biochim Biophys Acta. 1995 Feb 16;1265(1):93-5.

PMID: 7857990

Abstract:

In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively. Here, we demonstrate that the specific PKC inhibitor bisindolylmaleimide GF 109203X prevents only the inhibitory, but not the stimulatory, PMA effect.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP133052901-A GF 109203X GF 109203X 133052-90-1 Price
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