Home
Resources
Publications
The Broad Spectrum 2-oxoglutarate Oxygenase Inhibitor N-oxalylglycine Is Present in Rhubarb and Spinach Leaves

The Broad Spectrum 2-oxoglutarate Oxygenase Inhibitor N-oxalylglycine Is Present in Rhubarb and Spinach Leaves

Khalid Al-Qahtani, Bushra Jabeen, Rok Sekirnik, Naheed Riaz, Timothy D W Claridge, Christopher J Schofield, James S O McCullagh

Phytochemistry. 2015 Sep;117:456-461.

PMID: 26196940

Abstract:

2-Oxoglutarate (2OG) and ferrous iron dependent oxygenases are involved in many biological processes in organisms ranging from humans (where some are therapeutic targets) to plants. These enzymes are of significant biomedicinal interest because of their roles in hypoxic signaling and epigenetic regulation. Synthetic N-oxalylglycine (NOG) has been identified as a broad-spectrum 2OG oxygenase inhibitor and is currently widely used in studies on the hypoxic response and chromatin modifications in animals. We report the identification of NOG as a natural product present in Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves; NOG was not observed in Escherchia coli or human embryonic kidney cells (HEK 293T). The finding presents the possibility that NOG plays a natural role in regulating gene expression by inhibiting 2OG dependent oxygenases. This has significance because tricarboxylic acid cycle (TCA) intermediate inhibition of 2OG dependent oxygenases has attracted major interest in cancer research.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4244394	N-Oxalylglycine			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: