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[The Chemical Toxicological Investigation of Gamma-Hydroxybutyric Acid in Biological Objects and the Interpretation of the Results of the Analysis]

[The Chemical Toxicological Investigation of Gamma-Hydroxybutyric Acid in Biological Objects and the Interpretation of the Results of the Analysis]

I E Loban, T V Gorbacheva, V A Bychkov

Sud Med Ekspert. 2018;61(5):21-24.

PMID: 30307433

Abstract:

The authors propose a method for the quantitative determination of gamma-hydroxybutyric acid (GHBA) in biological objects including biological fluids (blood, urine) and tissues with the use of gas chromatography with mass-selective detector. The samples for the analysis were prepared by liquid-liquid extraction by butyl acetate with subsequent derivatization using a N,O-Bis(trimethylsilyl)trifluoroacetamide/Trimethylchlorosilane mixture (BSTFA + 1%TMCS). The graded graphs were linear in the range of GHBA concentrations from 26.4 to 1321.6 mg/l. Coefficients of correlation for all the graphs were higher than 0.999. The threshold of detectability for GHBA in blood, urine, and internal organs was 10 mg/l, the quantification limit concentration 26 mg/l.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25561302	N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane		25561-30-2	Price
AP25561302-A	BSTFA (with 1% TMCS)		25561-30-2	Price

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