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The Control of Nitrilotriacetic Acid in Edetic Acid and Its Salts by Liquid Chromatography

G A Crosbie, A Lodi, J H McB Miller, G G Skellern

J Pharm Biomed Anal. 2003 Oct 15;33(3):435-40.

PMID: 14550862

Abstract:

Two liquid chromatographic methods have been developed and validated for the determination of nitrilotriacetic acid (NTA) in edetic acid (EDTA) and its salts. In one method NTA and EDTA are separated on a polymer column without pretreatment, and are detected amperometrically using a glassy-carbon electrode. In the other method NTA and EDTA are complexed with ferric ions and the complexes separated on a porous graphite carbon stationary phase with ultraviolet detection at 215 nm. Both methods were sufficiently selected and sensitive to allow the control of NTA (0.1% m/m) in sample of EDTA and its salts.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP60004 Edetic acid Edetic acid 60-00-4 Price
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