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[The Distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the Organism of the Warm-Blooded Animals After Its Intra-Gastric Administration]

[The Distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the Organism of the Warm-Blooded Animals After Its Intra-Gastric Administration]

V K Shormanov, M F Pravdyuk, V Yu Kuzovlev, N V Shabunina

Sud Med Ekspert. 2018;61(2):36-44.

PMID: 29667636

Abstract:

The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance. It was shown that the largest amounts of 2-(dimethylamino)ethyl-(1-hydrpxycyclopentyl)(phenyl)acetate at the above time-points were present in the tissue of the stomach and small intestine, brain, muscles, spleen, and lungs of the animals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP122792	Phenyl acetate		122-79-2	Price

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