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The Effect of 5,8,11,14-eicosatetraynoic Acid on Endothelial Cell Gene Expression

The Effect of 5,8,11,14-eicosatetraynoic Acid on Endothelial Cell Gene Expression

K M Stuhlmeier, C Tarn, F H Bach

Eur J Pharmacol. 1997 May 1;325(2-3):209-19.

PMID: 9163568

Abstract:

The endothelium plays a key role in inflammation, hemostasis and organ rejection. We report here that a synthetic polyunsaturated fatty acid, 5,8,11,14-eicosatetraynoic acid (ETYA), selectively inhibits the up-regulation of several genes on endothelial cells. ETYA suppresses endothelial cell activation by inhibiting the up-regulation of adhesion molecules like E-selectin. A runoff assay for E-selectin demonstrated that the suppression is at the level of transcription. The fact that ETYA inhibits E-selectin upon stimulation with a diverse group of stimuli like lipopolysaccharide, tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, suggests that ETYA does not exert its effect by modifying membrane-bound receptors. The messenger RNA for interleukin-8 and glyceraldehyde phosphate dehydrogenase are not affected. Pre-treatment of endothelial cells with ETYA also prevents the adherence of monocytes to tumor necrosis factor-alpha-stimulated cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1191851-A	5,8,11,14-Eicosatetraynoic acid		1191-85-1	Price

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