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The Effect of a Nicorandil Congener on Isolated Human Myometrium

The Effect of a Nicorandil Congener on Isolated Human Myometrium

K Parimala, Jacob Peedicayil, Abraham Peedicayil, Nissy Nelson, Kalpana Ernest

Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):176-9.

PMID: 16216408

Abstract:

Objective:
To determine the effect of a nicorandil congener, SG-209 on the myometrium.
Study design:
Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.
Results:
At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).
Conclusion:
SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP83440033	SG-209		83440-03-3	Price

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