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The Effect of Anthralin (Dithranol) on Mitochondria

The Effect of Anthralin (Dithranol) on Mitochondria

P Morlière, L Dubertret, T Sa e Melo, C Salet, M Fosse, R Santus

Br J Dermatol. 1985 May;112(5):509-15.

PMID: 4005152

Abstract:

The short-term effect of topical application of anthralin (dithranol) on normal human skin was investigated by electron microscopy. Mitochondria appeared markedly damaged. By contrast other cellular structures, particularly the nuclear and cytoplasmic membranes were unchanged. In vitro experiments were therefore performed on isolated rat liver mitochondria and it was shown that anthralin acts as an uncoupler of oxidative phosphorylation. These results suggest that anthralin can inhibit the adenosine triphosphate supply in epidermal cells. This loss of energy supply in keratinocytes could explain, at least in part, the therapeutic efficiency of anthralin in psoriasis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1143380-B	Anthralin (Dithranol)		1143-38-0	Price

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