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[The Effect of Calcium Pantothenate and Homopantothenate on [14C]-GABA Absorption by Slices of Rat Cerebral Cortex]

[The Effect of Calcium Pantothenate and Homopantothenate on [14C]-GABA Absorption by Slices of Rat Cerebral Cortex]

T E Reĭtarova, V A Rozanov, M A Kovler, V M Kopelevich, V N Totskiĭ

Farmakol Toksikol. Jul-Aug 1988;51(4):25-9.

PMID: 3191967

Abstract:

Calcium D-pantothenate (Ca D-P) and calcium D-homopantothenate (Ca D-HP) (pantogam) exhibiting antagonism in a number tests of pharmacological screening were shown to inhibit the absorption of [14C]-GABA (0.2 microM) by the rat brain cortex slices (3 mm) incubated in calcium-free medium. The effect of Ca D-HP manifests at its low concentrations (10(-6) M) and that of Ca D-P at high concentrations (10(-6) M). The data obtained are discussed in relation to the possible influence of the anion and cation components of the studied compounds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP137086-B	Calcium-d-pantothenate		137-08-6	Price

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