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The Effect of Temperature and Chloride Ions on the Stimulation of [3H]flunitrazepam Binding by the Muscimol Analogues THIP and piperidine-4-sulfonic Acid

The Effect of Temperature and Chloride Ions on the Stimulation of [3H]flunitrazepam Binding by the Muscimol Analogues THIP and piperidine-4-sulfonic Acid

P Supavilai, M Karobath

Neurosci Lett. 1980 Oct 2;19(3):337-41.

PMID: 6133252

Abstract:

THIP and piperidine-4-sulfonic acid (PSA) interact with [3H]GABA binding sites and have GABAmimetic efficacy in vivo, but fail to enhance benzodiazepine receptor binding performed at 0 degree C. However, when [3H]flunitrazepam binding is determined at elevated temperature (30 or 37 degrees C), THIP and PSA display potent chloride ion-dependent stimulatory effects. These results resolve apparent discrepancies between the properties of GABA receptors observed in vivo and in vitro, and they suggest that the modulation of benzodiazepine receptor binding investigated at physiological temperatures can be used as an experimental system for the characterization of GABA receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72450625	Piperidine-4-sulfonic acid		72450-62-5	Price

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