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The Effect of Three Different Solutions on Preventing Oral Mucositis in Cancer Patients Undergoing Stem Cell Transplantation: A Non-Randomized Controlled Trial: A Turkish Study - NON-RANDOMISED TRIAL

The Effect of Three Different Solutions on Preventing Oral Mucositis in Cancer Patients Undergoing Stem Cell Transplantation: A Non-Randomized Controlled Trial: A Turkish Study - NON-RANDOMISED TRIAL

Merve Harman, Nimet Ovayolu, Ozlem Ovayolu

J Pak Med Assoc. 2019 Jun;69(6):811-816.

PMID: 31189287

Abstract:

Objective:
To evaluate the effect of different solutions administered to patients undergoing stem cell transplantation on oral mucositis.
Methods:
The non-randomised controlled trial was conducted at a Istanbul Medipol Mega university hospital in Turkey between May 2014 and June 2016, and comprised patients undergoing stem cell transplantation. They were divided into three groups. Group 1 had patients using chlorhexidine gluconate and benzydamine hydrochloride solution. Group 2 had those using calcium and phosphate solution. Group 3 patients were using black mulberry syrup. Data was collected using a structured questionnaire and the World Health Organisation mucositis assessment scale. Assessment was done on days 7, 14 and 21. Clinical significance of oral solutions was statistically determined.
Results:
Of the 83 patients, 30(36%) were in group 1, 28(34%) in group 2, and 25(30%) in group 3. On day 7, there was no significant difference in terms of grades among the groups (p>0.05). On day 14, grade 2 mucositis was seen in 2(8%) patents in group 3, 5(17.9%) in group 2 and 5(16.7%) in group 1; Grade 3 mucositis was seen in 2(6.7%) patients in group 1, but none in the other two groups. On day 21, grade 3 mucositis was present in 2(8.0%) in group 3, 2(7.1%) in group 2, and 4(13.3%) in group 1.
Conclusions:
The use of black mulberry and calcium-phosphate solutions was found to be beneficial in preventing and treating oral mucositis.

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