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[The Effect of Topical Application of 5-fluorouracil on Patency Times After Incisional Myringotomy of Guinea Pig Tympanic Membrane]

[The Effect of Topical Application of 5-fluorouracil on Patency Times After Incisional Myringotomy of Guinea Pig Tympanic Membrane]

Mehmet Eken, Cenk Evren, Günay Ateş, Ziya Bozkurt, Arif Sanli, Sedat Aydin

Kulak Burun Bogaz Ihtis Derg. 2006;16(5):209-13.

PMID: 17124440

Abstract:

Objectives:
We investigated the effect of topical application of 5-fluorouracil after incisional myringotomy on the patency time and its use as an alternative to ventilation tube insertion.
Materials and methods:
Experimental tympanic membrane perforations were induced in two groups of guinea pigs. One group (20 tympanic membranes) was treated with a 50 mg/ml 5-fluorouracil-soaked sponge over the perforation for five minutes while the other (16 tympanic membranes) with saline-soaked sponges for the same duration. The patency times, otorrhea, and other complications were recorded.
Results:
The mean patency of tympanic membrane perforations following incisional myringotomy was significantly longer in the 5-fluorouracil-treated group (11.3 days vs 7.0 days; p<0.01). None of the ears exhibited permanent perforation.
Conclusion:
The length of patency provided by 5-fluorouracil is not sufficient for optimal ventilation time in otitis media with effusion. However, in circumstances in which shorter patency times may provide sufficient ventilation, 5-fluorouracil application may be an alternative to ventilation tube insertion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42411746	Auresine			Price

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