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[The Effect of Topical mitomycin-C Application Before or After Incisional Myringotomy on Patency Times of Guinea Pig Tympanic Membrane Perforations]

[The Effect of Topical mitomycin-C Application Before or After Incisional Myringotomy on Patency Times of Guinea Pig Tympanic Membrane Perforations]

Cenk Evren, Mehmet Eken, Günay Ateş, Ziya Bozkurt, Arif Sanli

Kulak Burun Bogaz Ihtis Derg. 2007;17(2):100-4.

PMID: 17527062

Abstract:

Objectives:
The aim of this study was to investigate the effect of topical mitomycin-C application before or after incisional myringotomy on patency times and to asess its use as an alternative to ventilation tube insertion.
Materials and methods:
Nineteen guinea pigs were divided into two groups. In the study group (n=11), mitomycin-C was applied in a concentration of 0.4 mg/ml over the perforation for five minutes before (n=6) or after (n=5) incisional myringotomies in both ears. Control animals (n=8) received 0.1 ml 0.09% NaCl for the same duration. Evaluations were made on days 1, 3, 5, 7, 10, 14, and 21. The patency times, otorrhea, and other complications were recorded.
Results:
Compared to controls (7.0+/-1.5 days), the mean patency times of perforations were significantly longer in mitomycin-C treated groups before (11.6+/-5.2 days) and after (14.2+/-4.7 days) incisional myringotomies (p<0.05). Patency times did not differ significantly between the two mitomycin-C groups. None of the ears exhibited permanent perforation.
Conclusion:
The length of patency provided by mitomycin-C is not sufficient for optimal ventilation in otitis media with effusion. However, in cases requiring shorter patency times, mitomycin-C application before or after myringotomy may be an alternative to ventilation tube insertion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42411746	Auresine			Price

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