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The Effect of Various Saccharin Forms on Gastro-Intestinal Tract, Urine and Bladder of Male Rats

The Effect of Various Saccharin Forms on Gastro-Intestinal Tract, Urine and Bladder of Male Rats

R L Anderson, F R Lefever, J K Maurer

Food Chem Toxicol. 1988 Aug;26(8):665-9.

PMID: 3198034

Abstract:

Sodium saccharin, potassium saccharin, calcium saccharin and the free acid when fed to young male rats at a level of about 200 mumol/g diet all produced an equivalent increase in the caecal enlargement indicating that this phenomenon was due to the saccharin ion and not the accompanying cation. The sodium and potassium salts caused greater polydipsia and polyuria than the calcium or free acid forms. Simple hyperplasia of the bladder was noted in the rats ingesting the sodium and potassium salts but not in those ingesting the calcium or free acid forms. The difference in urine and bladder response to the salt forms is not attributable to the difference in the total urinary saccharin or the urinary concentration of saccharin. These results suggest that excess water absorption from the lower bowel and the concomitant bladder responses are dependent upon monovalent cation absorption but independent of saccharin absorption.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6381915	Saccharin calcium		6381-91-5	Price

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