Home
Resources
Publications
The Effect of Viscosity, Friction, and Sonication on the Morphology and Metabolite Production From Aspergillus Terreus ATCC 20542

The Effect of Viscosity, Friction, and Sonication on the Morphology and Metabolite Production From Aspergillus Terreus ATCC 20542

Muhamad Hafiz Abd Rahim, Hanan Hasan, Hanis H Harith, Ali Abbas

Bioprocess Biosyst Eng. 2017 Dec;40(12):1753-1761.

PMID: 28879627

Abstract:

This study investigates the effects of viscosity, friction, and sonication on the morphology and the production of lovastatin, (+)-geodin, and sulochrin by Aspergillus terreus ATCC 20542. Sodium alginate and gelatine were used to protect the fungal pellet from mechanical force by increasing the media viscosity. Sodium alginate stimulated the production of lovastatin by up to 329.0% and sulochrin by 128.7%, with inhibitory effect on (+)-geodin production at all concentrations used. However, the use of gelatine to increase viscosity significantly suppressed lovastatin, (+)-geodin, and sulochrin's production (maximum reduction at day 9 of 42.7, 60.8, and 68.3%, respectively), which indicated that the types of chemical play a major role in metabolite production. Higher viscosity increased both pellet biomass and size in all conditions. Friction significantly increased (+)-geodin's titre by 1527.5%, lovastatin by 511.1%, and sulochrin by 784.4% while reducing pellet biomass and size. Conversely, sonication produced disperse filamentous morphology with significantly lower metabolites. Sodium alginate-induced lovastatin and sulochrin production suggest that these metabolites are not affected by viscosity; rather, their production is affected by the specific action of certain chemicals. In contrast, low viscosity adversely affected (+)-geodin's production, while pellet disintegration can cause a significant production of (+)-geodin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP519573	Sulochrin		519-57-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: