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The Effect of Vitamin D and Selenomethionine on Thyroid Antibody Titers, Hypothalamic-Pituitary-Thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: A Pilot Study

The Effect of Vitamin D and Selenomethionine on Thyroid Antibody Titers, Hypothalamic-Pituitary-Thyroid Axis Activity and Thyroid Function Tests in Men With Hashimoto's Thyroiditis: A Pilot Study

Robert Krysiak, Witold Szkróbka, Bogusław Okopień

Pharmacol Rep. 2019 Apr;71(2):243-247.

PMID: 30818086

Abstract:

Background:
Both selenium and vitamin D were found to reduce thyroid antibody titers in women with Hashimoto's thyroiditis.
Methods:
The study enrolled 37 young drug-naïve euthyroid men with autoimmune thyroiditis, who were treated for 6 months with either exogenous vitamin D (group A, n = 20) or selenomethionine (group B, n = 17). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin and free thyroid hormones, serum levels of 25-hydroxyvitamin D, as well Jostel's thyrotropin, the SPINA-GT and the SPINA-GD indices were determined at the beginning and at the end of the study.
Results:
At baseline, there were no differences between the study groups. Both vitamin D and selenomethionine reduced antibody titers and increased the SPINA-GT index. Only selenomethionine affected the SPINA-GD index, while only vitamin D increased 25-hydroxyvitamin D levels. Neither selenomethionine nor vitamin D significantly affected thyrotropin and free thyroid hormone levels. The effect of vitamin D on antibody titers correlated with baseline and treatment-induced changes in serum levels of 25-hydroxivitamin D.
Conclusions:
Both vitamin D and selenomethionine have a beneficial effect on thyroid autoimmunity in drug-naïve men with Hashimoto's thyroiditis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3211765-A	Selenomethionine		3211-76-5	Price

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