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The Effects of Biodentine/polycaprolactone Three-Dimensional-Scaffold With Odontogenesis Properties on Human Dental Pulp Cells

The Effects of Biodentine/polycaprolactone Three-Dimensional-Scaffold With Odontogenesis Properties on Human Dental Pulp Cells

C-C Ho, H-Y Fang, B Wang, T-H Huang, M-Y Shie

Int Endod J. 2018 May;51 Suppl 4:e291-e300.

PMID: 28631418

Abstract:

Aim:
To determine the feasibility of using three-dimensional printed Biodentine/polycaprolactone composite scaffolds for orthopaedic and dental applications. The physicochemical properties and the odontogenic differentiation of human dental pulp cells (hDPCs) were investigated.
Methodology:
Biodentine was well-suspended in ethanol and dropped slowly into molten polycaprolactone with vigorous stirring. The Biodentine/polycaprolactone composite scaffolds were then fabricated into controlled macropore sizes and structures using an extrusion-based three-dimensional (3D) printer. The mechanical properties, bioactivity, and the proliferation and odontogenic differentiation of human dental pulp cells (hDPCs) cultured on the scaffolds were evaluated.
Results:
Biodentine/polycaprolactone scaffolds had uniform macropores 550 μm in size with established interconnections and a compressive strength of 6.5 MPa. In addition, the composite scaffolds exhibited a good apatite-forming ability and were capable of supporting the proliferation and differentiation of hDPCs.
Conclusion:
The composite scaffolds fabricated by an extrusion-based 3D printing technique had similar characteristics to Biodentine cement, including bioactivity and the ability to promote the differentiation of hDPCs. These results indicate that the composite scaffold would be a candidate for dental and bone regeneration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24980414	Polycaprolactone		24980-41-4	Price

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