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The Effects of Lindane Poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine Concentrations in the Brain of Locusta Migratoria L

The Effects of Lindane Poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine Concentrations in the Brain of Locusta Migratoria L

B Moreteau, N Chaminade

Ecotoxicol Environ Saf. 1990 Aug;20(1):115-20.

PMID: 1699720

Abstract:

High-performance liquid chromatography with electrochemical detection was used to measure N-acetyldopamine and N-acetyl 5-hydroxytryptamine in the cerebral ganglia of the African migratory locust, Locusta migratoria (fifth instar) exposed to lindane, a chlorinated insecticide. Locusts were poisoned by this insecticide in order to assess the effects of this neuroactive compound on these acetylated metabolites levels. Relatively low concentrations of N-acetyldopamine were observed in the cerebral ganglia. Incubation of ganglia resulted in increased concentrations of N-acetyldopamine and N-acetyl 5-hydroxytryptamine. Lindane significantly reduces N-acetyldopamine and N-acetyl 5-hydroxytryptamine levels in the cerebral ganglia. These results can be correlated with a decrease in N-acetyltransferase activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1210839	N-Acetyl-5-hydroxytryptamine		1210-83-9	Price

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