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The Effects of Multistrain Probiotic Compound on Bismuth-Containing Quadruple Therapy for Helicobacter Pylori Infection: A Randomized Placebo-Controlled Triple-Blind Study

The Effects of Multistrain Probiotic Compound on Bismuth-Containing Quadruple Therapy for Helicobacter Pylori Infection: A Randomized Placebo-Controlled Triple-Blind Study

Ahmad Shavakhi, Elham Tabesh, Arezoo Yaghoutkar, Houriye Hashemi, Faezeh Tabesh, Mahsa Khodadoostan, Mohammad Minakari, Sara Shavakhi, Ali Gholamrezaei

Helicobacter. 2013 Aug;18(4):280-4.

PMID: 23433200

Abstract:

Background:
Evidence has shown benefits of single-strain probiotics for Helicobacter pylori eradication. We investigated the effects of adding a multistrain probiotic compound on bismuth-containing quadruple therapy for H. pylori infection.
Materials and methods:
Adult patients with peptic ulcer disease and confirmed H. pylori infection (n = 180) were randomized to receive bismuth-containing quadruple therapy (omeprazole, bismuth subcitrate, amoxicillin, and clarithromycin) plus a probiotic compound or placebo for 2 weeks. The probiotic compound contained seven bacterial species including Lactobacillus and Bifidobacterium strains and Streptococcus thermophiles. Eradication of H. pylori was assessed 4 weeks after medication by (13) C urea breath test. Other outcomes were dyspepsia symptoms, therapy-related adverse effects, and patient's tolerance.
Results:
Eighty-four patients in the probiotic and 86 in the placebo group completed the trial. With per-protocol (intention to treat) analysis, H. pylori was eradicated in 82.1% (76.6%) of the probiotic and 84.8% (81.1%) of the placebo group, p = .392 (0.292). Symptoms were significantly improved with similar trends in both groups. Regarding the adverse effects, diarrhea was less frequent (2.2 vs 11.1%, p = .016), while abdominal pain was more frequent (10 vs 2.2%, p = .029) in the probiotic group. The two groups were similar in treatment tolerance (p = .851).
Conclusions:
In overall, our studied multistrain probiotic compound has not beneficial effects in the treatment of H. pylori infection. It might be related to the low dosage of our probiotic regimen and/or high frequency of upper gastrointestinal adverse effects which in turn could decrease the eradication efficacy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS3104571	Amoxicillin Related Compound C			Price

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