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The Effects of Nodakenin on Airway Inflammation, Hyper-Responsiveness and Remodeling in a Murine Model of Allergic Asthma

The Effects of Nodakenin on Airway Inflammation, Hyper-Responsiveness and Remodeling in a Murine Model of Allergic Asthma

Youyi Xiong, Junsong Wang, Hao Yu, Xiaolin Zhang, Chenggui Miao, Shitang Ma

Immunopharmacol Immunotoxicol. 2014 Oct;36(5):341-8.

PMID: 25090633

Abstract:

Context:
Nodakenin is a major coumarin glucoside in the root of Peucedanum decursivum Maxim, a commonly used traditional Chinese medicine for the treatment of asthma and chronic bronchitis for thousands of years.
Objective:
In this work, the anti-asthma potential of nodakenin was studied by investigation of its effect to suppress airway inflammation, hyper-responsiveness and remodeling in a murine model of chronic asthma.
Materials and methods:
BALB/c mice sensitized to ovalbumin (OVA) were challenged with aerosolized OVA for 8 weeks, orally administered with nodakenin at doses of 5, 10 and 20 mg/kg before each OVA challenge.
Results:
Compared with the model group, nodakenin treatment markedly inhibited airway inflammation, hyper-responsiveness and remodeling, showing improvement in subepithelial fibrosis, smooth muscle hypertrophy, and goblet cell hyperplasia, and decreased levels of interleukin (IL)-4, IL-5, IL-13 and matrix metalloproteinase-2/-9 in bronchoalveolar lavage fluid, and the level of OVA-specific IgE in serum. In addition, the NF-κB DNA-binding activity in lung tissues was also reduced by nodakenin treatment.
Conclusions:
These data indicated that nodakenin might mitigate the development of chronic experimental allergic asthma.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP495318	Nodakenin		495-31-8	Price

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