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The Effects of Pinoresinol on Cholinergic Dysfunction-Induced Memory Impairments and Synaptic Plasticity in Mice

The Effects of Pinoresinol on Cholinergic Dysfunction-Induced Memory Impairments and Synaptic Plasticity in Mice

Jimin Yu, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Rae Hee Kang, Kumju Youn, Mira Jun, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim

Food Chem Toxicol. 2019 Mar;125:376-382.

PMID: 30685474

Abstract:

Dementia is a category of brain diseases that cause a decrease in cognitive functions. Alzheimer's disease (AD) is the most frequently mentioned neurodegenerative disease showing dementia. Although many useful drugs for dementia were developed, we still need better and safer drugs. Here, we tested pinoresinol, a lignan found in sesame seed and olive oil, whether it could be a candidate for this purpose. Pinoresinol (25 mg/kg, p.o.) ameliorated memory impairment in dementia model induced by cholinergic blockade in the passive avoidance test in a dose-dependent manner. Moreover, pinoresinol (50 μM) facilitated induction of hippocampal long-term potentiation, a cellular model of learning and memory. Pinoresinol blocked acetylcholinesterase (AchE), an acetylcholine-degrading enzyme, activity in a concentration-dependent manner. Moreover, pinoresinol (50 μM) facilitated calcium influx into neuro2a cell. These results suggest that pinoresinol improves memory impairment and facilitates hippocampal LTP induction and these results might be related to the effect of pinoresinol on AChE and calcium influx.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP487365	Pinoresinol		487-36-5	Price

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