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The Effects of Rhodium on the Renal Function of Female Wistar Rats

The Effects of Rhodium on the Renal Function of Female Wistar Rats

Ivo Iavicoli, Veruscka Leso, Luca Fontana, Alessandro Marinaccio, Antonio Bergamaschi, Edward J Calabrese

Chemosphere. 2014 Jun;104:120-5.

PMID: 24321336

Abstract:

In recent years, the increased use of rhodium (Rh) as an active catalyst material in modern three-way automobile catalytic converters has led to a parallel rise in environmental levels of this metal. In spite of this, the literature contains few studies of the effects of Rh on human health. The aim of this study is to assess the effects of Rh on the renal function of female Wistar rats. Our findings show that sub-acute exposure to six increasing concentrations, ranging from 0.001 to 1 mg L(-1), of Rh (III) chloride hydrate in drinking water does not induce alterations in urinary albumin levels, while, at concentrations from 0.1 to 1 mg L(-1), a significant rise in urinary levels of Retinol Binding Protein is evident and an increasing trend in urinary β2-microglobulin, which becomes significant at 1 mg L(-1), is observed. These results therefore demonstrate a nephrotoxic action of Rh at tubular level in a wide range of doses. Interestingly, because of the recent increase in environmental Rh levels, these findings may have relevant implications both for occupationally exposed subjects and for the general population, especially children.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP20765984	Rhodium(III) chloride hydrate		20765-98-4	Price

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