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The Effects of Succinylacetone (4,6-dioxoheptanoic Acid) on Delta-Aminolevulinate Synthase Activity and the Content of Heme in Monolayers of Chick Embryo Liver Cells

N Schoenfeld, Y Greenblat, O Epstein, A Atsmon

Biochim Biophys Acta. 1982 Dec 30;721(4):408-17.

PMID: 7159602

Abstract:

Succinylacetone was shown to inhibit aminolevulinate dehydratase (5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24) to reduce cellular heme and porphyrins and to induce delta-aminolevulinate synthase (succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37) in monolayers of chick embryo liver cells. Marked synergistic effects on delta-aminolevulinate synthase activity were obtained by combining succinylacetone with levulinate and porphyrogenic drugs. The time course of delta-aminolevulinate synthase activity showed a delayed synergistic response.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP51568184 4,6-Dioxoheptanoic acid 4,6-Dioxoheptanoic acid 51568-18-4 Price
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