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The Effects of Vitamins and Selenium Mixture Against Brain Tissue Induced by D-Galactosamine

The Effects of Vitamins and Selenium Mixture Against Brain Tissue Induced by D-Galactosamine

Sevim Tunali, Tunc Catal, Sehnaz Bolkent, Refiye Yanardag

J Biochem Mol Toxicol. 2019 Aug;33(8):e22347.

PMID: 31022331

Abstract:

Brain damage is a major complication of fulminant hepatic failure. d-Galactosamine (d-GalN)-induced liver toxicity causes damage to brain. The effects of vitamins and selenium mixture against d-GalN stimulated brain injury were investigated in this study. Sprague-Dawley female rats aged 2.0-2.5 months were used for the study. The rats were divided into four categories. A 0.9% NaCl solution was intraperitoneally given to the experimental rats in the first group. Using gavage technique, the second group of animals were subjected to a formulation consisting of 100 mg·kg-1 ·day-1 vitamin C, 15 mg·kg-1 ·day-1 of β-carotene, 100 mg·kg-1 ·day-1 of α-tocopherol in addition to 0.2 mg·kg-1 ·day-1 of sodium selenate for 3 days. The third group was given a single dose of d-GalN hydrochloride at the concentration of 500 mg·kg-1 through a saline injection. The final group was given similar concentrations of both the antioxidant combination and d-GalN. Tissue samples were collected under ether anesthesia. The rats treated with d-GalN showed brain damage; increased myeloperoxidase, catalase, glutathione peroxidase, glutathione-S-transferase, lactate dehydrogenase, and superoxide dismutase activities; and decreased glutathione levels. Treatment with vitamins and selenium combination resulted in alleviation of these alterations in the rats. These findings suggest that administration of the vitamins and selenium combination suppresses oxidative stress and protects brain cells from injury induced by d-GalN.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10191410-A	(±)−α−Tocopherol (Vitamin E) solution		10191-41-0	Price

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