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The Effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on Feeding in the Rat

The Effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on Feeding in the Rat

J E Hartley, A Fletcher

Eur J Pharmacol. 1994 Feb 11;252(3):329-32.

PMID: 8162954

Abstract:

We have examined the effects of the selective 5-HT1A receptor antagonist, WAY-100135, on feeding and on 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced hyperphagia in rats. Given alone, WAY-100135 (1-10 mg/kg s.c.) did not affect the food intake of fasted or satiated rats; however, in free feeding rats, WAY-100135 (3 mg/kg s.c.) significantly attenuated 8-OH-DPAT-induced hyperphagia (0.1 mg/kg s.c.). Using a satiety sequence analysis of feeding behaviour, WAY-100135 (1 mg/kg s.c.) did not affect behaviour per se, but significantly antagonised the increased incidence of feeding, but not the decrease in observations of grooming following 8-OH-DPAT (0.1 mg/kg s.c.). These data provide the first demonstration of the antagonism, by a selective 5-HT1A receptor antagonist, of 8-OH-DPAT-induced feeding; an effect mediated via the somatodendritic 5-HT1A autoreceptor. These results also suggest that 5-HT1A receptor antagonists may have no intrinsic effect on food intake or feeding behaviour.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP149055798	WAY-100135		149055-79-8	Price

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