Home
Resources
Publications
The Fate of Trans-Caftaric Acid Administered Into the Rat Stomach

The Fate of Trans-Caftaric Acid Administered Into the Rat Stomach

Andreja Vanzo, Roberto Cecotti, Urska Vrhovsek, Adriana M Torres, Fulvio Mattivi, Sabina Passamonti

J Agric Food Chem. 2007 Feb 21;55(4):1604-11.

PMID: 17300159

Abstract:

trans-Caftaric acid is the most abundant nonflavonoid phenolic compound in grapes and wines. It occurs in chicory and is one of the bioactive components of Echinacea purpurea. In order to fill the gap of knowledge about its bioavailability in mammals, we investigated its absorption, tissue distribution, and metabolism in rats. Assuming that the stomach is a relevant site of absorption of dietary polyphenols, a solution of trans-caftaric acid was maintained in the ligated stomach of anaesthetized rats for 20 min. Intact trans-caftaric acid was detected in rat plasma at both 10 and 20 min (293 +/- 45 and 334 +/- 49 ng/mL, respectively), along with its O-methylated derivative trans-fertaric acid, whose concentration rose over time (from 92 +/- 12 to 185 +/- 24 ng/mL). At 20 min, both trans-caftaric acid and trans-fertaric acid were detected in the kidney (443 +/- 78 and 2506 +/- 514 ng/g, respectively) but not in the liver. Only trans-fertaric acid was found in the urine (33.3 +/- 12.8 microg/mL). In some rats, trans-caftaric acid was detected in the brain (180 +/- 20 ng/g).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67879587	Caftaric acid		67879-58-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: