Home
Resources
Publications
The First Inorganic Mitogens: Cerium Oxide and Cerium Fluoride Nanoparticles Stimulate Planarian Regeneration via Neoblastic Activation

The First Inorganic Mitogens: Cerium Oxide and Cerium Fluoride Nanoparticles Stimulate Planarian Regeneration via Neoblastic Activation

Artem Ermakov, Anton Popov, Olga Ermakova, Olga Ivanova, Alexander Baranchikov, Kristina Kamenskikh, Taisiya Shekunova, Alexander Shcherbakov, Nelli Popova, Vladimir Ivanov

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109924.

PMID: 31499991

Abstract:

We report the first experimental evidence for the mitogenic action of cerium(IV) oxide and cerium(III) fluoride nanoparticles (CONs and CFNs) on the regeneration of a whole organism - freshwater flatworms Schmidtea mediterranea (planarian). Both types of cerium-containing nanoparticles are shown to be a highly potent mitogen for planaria. Both CONs and CFNs, in micro- and nanomolar concentrations, markedly accelerate planarian blastema growth, due to the enhancement of cellular proliferation, causing an increase in the mitotic index and in the quantity of blastema cells in regenerating planaria. CONs provided maximum activity at concentrations which were two orders of magnitude lower than those for CeF3. The valence state of cerium in cerium-containing nanoparticles plays a significant role in the planarian regeneration mechanism: CeO2 nanoparticles containing predominantly Ce4+ species presumably scavenge wound induced reactive oxygen species and moderately activate gene expression processes, while the regenerative action of CeF3 nanoparticles containing only Ce3+ species is manifested in the pronounced expression of the genes involved in cell division, differentiation and migration. This is the first report on the effect of cerium-containing nanoparticles on tissue regeneration in vivo, further revealing the mechanisms of their biological action, which enhances the possibility of their use in cellular technologies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1306383	Cerium(IV) oxide		1306-38-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: