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The First One-Pot Synthesis of Undoped and Eu Doped β-NaYF4 Nanocrystals and Their Evaluation as Efficient Dyes for Nanomedicine

The First One-Pot Synthesis of Undoped and Eu Doped β-NaYF4 Nanocrystals and Their Evaluation as Efficient Dyes for Nanomedicine

Walid Mnasri, Lotfi Ben Tahar, Michel Boissière, Darine Abi Haidar, Souad Ammar

Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:26-34.

PMID: 30423708

Abstract:

Polygonal-shaped about 75 nm sized and highly crystallized Eu3+-doped β-NaYF4 particles were directly prepared under mild conditions using the polyol process. A set of operating parameters were optimized for such a purpose. A conventional heating under reflux for 30 min of a mixture of Y(III) and Eu(III) acetate, ammonium fluoride, sodium hydroxide and oleic acid (OA) dissolved in ethyleneglycol offered a pertinent material processing route if a large excess of NH4F and an enough amount of OA were used. Typically, the former parameter provides an exclusive stabilization of the desired β allotropic form, while the latter allows a significant size decrease of the particles. Thanks to their coating by a double OA layer, the produced particles exhibited a hydrophilic surface feature when dispersed in water and when excited under UV light they emitted a very intense red photoluminescence. Additionally, they did not evidence any accurate cytotoxicity when incubated with healthy human foreskin fibroblast (BJH) cells for doses as high as 50 μg·mL-1 and contact time as long as 48 h, highlighting the ability of the prepared particles to be used as efficient down-converter light sources for cell labelling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13765258	Europium(III) fluoride		13765-25-8	Price

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