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The Formation of Cyclized Silyl Derivatives of Beta-Hydroxyamines and Their Analyses by Means of Gas Chromatography Mass Spectrometry

C G Hammar

Biomed Mass Spectrom. 1978 Jan;5(1):25-8.

PMID: 623889

Abstract:

A generally applicable silylation method for beta-hydroxylated primary, secondary, tertiary and even quaternary amines is presented. These aminoalcohols form 6-membered heterocycles under the influence of a reagent mixture consisting of 1,3-bis-(chloromethyl)-1,1,3,3-tetramethyldisilazane and chloromethyldimethyl-chlorosilane. Examples of analogue ring closures with a gamma-hydroxyamine and an alpha-amino acid are also given. The formation of the derivatives and their properties, are discussed, mainly from the viewpoint mass spectrometry.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP15933592 1,1,3,3-Tetramethyldisilazane 1,1,3,3-Tetramethyldisilazane 15933-59-2 Price
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