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The Genotoxicity of Organotin Compounds in SOS Chromotest and Rec-Assay

T Hamasaki, T Sato, H Nagase, H Kito

Mutat Res. 1992;280(3):195-203.

PMID: 1381483

Abstract:

In these days pollution by organotin compounds in the environment extends widely and effects on human health are feared. We studied the genotoxicity of various organotin compounds (butyltins, phenyltins, methyltins) and inorganic tin (SnCl4), which are present in the environment, with the SOS chromotest and the rec-assay. Mono-n-butyltin oxide, n-butyltin trichloride and di-n-butyltin dichloride showed high SOS-inducing potency in the SOS chromotest with Escherichia coli PQ37. Di-n-butyltin dichloride, tri-n-butyltin chloride, bis(tri-n-butyltin)oxide, dimethyltin dichloride and trimethyltin chloride were recognized as genotoxic chemicals by the rec-assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP993168 Methyltin trichloride Methyltin trichloride 993-16-8 Price
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