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The Human Adrenal Microsomal glucose-6-phosphatase System

The Human Adrenal Microsomal glucose-6-phosphatase System

R Hume, M Voice, S Pazouki, R Giunti, A Benedetti, A Burchell

J Clin Endocrinol Metab. 1995 Jun;80(6):1960-6.

PMID: 7775646

Abstract:

Microsomal glucose-6-phosphatase (EC 3.1.3.9) is a multicomponent enzyme system traditionally thought only to be present in gluconeogenic tissues. The enzyme is associated with transport systems, for its substrate glucose-6-phosphate, and its products phosphate and glucose. It has been shown, using immunohistochemical methods and monospecific antibodies, that the component proteins of the enzyme system are present in human embryonic and fetal adrenal gland and are predominantly located in the fetal zone with lesser reactivities in the definitive zone. In addition, specific glucose-6-phosphatase activity was shown, and the rates of entry of glucose-6-phosphate, phosphate, and glucose into microsomes isolated from human fetal adrenals were measured. Although the complete enzyme system is present, the ratio of the component activities and comparison with human fetal and adult liver indicate that the regulation of the adrenal and liver glucose-6-phosphatase systems is different. In the human postnatal adrenal, immunoreactivies to the protein components decrease dramatically and are confined predominantly to the zona reticularis, suggesting a specialized role for adrenal glucose-6-phosphatase in fetal life.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103192558	D-Glucose 6-phosphate potassium salt		103192-55-8	Price

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