Home
Resources
Publications
The Human Pyridoxal Kinase, a Plausible Target for Ginkgotoxin From Ginkgo Biloba

The Human Pyridoxal Kinase, a Plausible Target for Ginkgotoxin From Ginkgo Biloba

Uta Kästner, Christian Hallmen, Michael Wiese, Eckhard Leistner, Christel Drewke

FEBS J. 2007 Feb;274(4):1036-45.

PMID: 17250738

Abstract:

Ginkgotoxin (4'-O-methylpyridoxine) occurring in the seeds and leaves of Ginkgo biloba, is an antivitamin structurally related to vitamin B(6). Ingestion of ginkgotoxin triggers epileptic convulsions and other neuronal symptoms. Here we report on studies on the impact of B(6) antivitamins including ginkgotoxin on recombinant homogeneous human pyridoxal kinase (EC 2.7.1.35). It is shown that ginkgotoxin serves as an alternate substrate for this enzyme with a lower K(m) value than pyridoxal, pyridoxamine or pyridoxine. Thus, the presence of ginkgotoxin leads to temporarily reduced pyridoxal phosphate formation in vitro and possibly also in vivo. Our observations are discussed in light of Ginkgo medications used as nootropics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1464331	Ginkgotoxin		1464-33-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: