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The Human Ubiquitin-Conjugating Enzyme UbcH1 Is Involved in the Repair of UV-damaged, Alkylated and Cross-Linked DNA

P Kaiser, H A Mansour, T Greeten, B Auer, M Schweiger, R Schneider

FEBS Lett. 1994 Aug 15;350(1):1-4.

PMID: 8062904

Abstract:

The human ubiquitin-conjugating enzyme UbcH1 shows 69% identity to the Saccharomyces cerevisiae RAD6/UBC2 which plays a key role in DNA repair. To examine the function of UbcH1 (formerly named E2, M(r) 17,000), [(1990) EMBO J. 9, 1431-1435]) we tested its ability to functionally substitute for yeast RAD6/UBC2 in the recovery of cells from various DNA damage. Complementation by expression of the human UbcH1 cDNA revealed that the UbcH1 carries out the function of S. cerevisiae RAD6/UBC2 in the repair of UV-damaged, alkylated and cross-linked DNA.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42415055 UbcH1 human UbcH1 human Price
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