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The IL-2/IL-2-receptor Complex in the Maturation of Rat T-cell Progenitors

The IL-2/IL-2-receptor Complex in the Maturation of Rat T-cell Progenitors

A Varas, T Romo, E Jiménez, L Alonso, A Vicente, A G Zapata

Dev Immunol. 1998;6(1-2):141-7.

PMID: 9716915

Abstract:

On the basis of both the interleukin-2-receptor (IL-2R) alpha-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For this purpose, we analyzed the effects of the addition of either recombinant rat IL-2 or anti-CD25 (OX-39)-blocking monoclonal antibodies to fetal thymus organ cultures (FTOC), established from 16-day-old rat embryos. IL-2 stimulated the growth of thymocytes and, as a result, induced T-cell differentiation, whereas OX-39 mAb blocked the maturation of thymic-cell progenitors. Accordingly, these results support the involvement of IL-2/IL-2R complex in rat T-cell development.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248758	IL-2 from rat			Price

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