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The Immunoglobulins of Mice. II. Two Subclasses of Mouse 7S Gamma-2-Globulins: Gamma-2A- and Gamma-2B-Globulins

The Immunoglobulins of Mice. II. Two Subclasses of Mouse 7S Gamma-2-Globulins: Gamma-2A- and Gamma-2B-Globulins

J L FAHEY, J WUNDERLICH, R MISHELL

J Exp Med. 1964 Aug 1;120(2):243-51.

PMID: 14206439

Abstract:

Two subclasses of mouse 7S gamma(2)-globulins are identified, and are designated gamma(2a)- and gamma(2b)-globulins. They are distinguished from 7S gamma(1)-globulins, gamma(1A) (beta(2A))-globulins, and gamma(1M)-globulins of mouse serum. Antibody activity was detected among the gamma(2a)-globulins and gamma(2b)-globulins of hyperimmune mouse serum. gamma(2a)- and gamma(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on gamma(2a)-myeloma proteins, but not on gamma(2b)-myeloma proteins. These findings indicate a complexity among the 7S gamma(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9007834-B	γ-Globulins from mouse		9007-83-4	Price

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