Home
Resources
Publications
[The In-Vitro Effects of Arbidol Hydrochloride Against 2009 New Influenza Virus A (H1N1)]

[The In-Vitro Effects of Arbidol Hydrochloride Against 2009 New Influenza Virus A (H1N1)]

Xing-quan Zhang, Jun-peng Dai, Bai-qiang Cai

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Apr;34(2):126-9.

PMID: 22776596

Abstract:

Objective:
To detect the in-vitro effects of arbidol hydrochloride against 2009 new influenza virus A (H1N1).
Methods:
The activity of arbidol hydrochloride against 2009 new influenza virus A (H1N1) was determined in MDCK cell cultures. Hemagglutination assay, observation of cytopathic effects, RT-PCR and quantitative RT-PCR tests were performed for determination of virus titers. Inhibition concentration 50% and cytotoxic concentration 50% were calculated with Chou's Menu of Dose-Effect Program.
Results:
Arbidol hydrochloride showed low cytotoxicity (cytotoxic concentration 50%>100 μmol/L)and significant anti-2009 new influenza virus A (H1N1) activity in cell cultures. Inhibition concentration 50% were (5.5 ± 0.9), (3.4 ± 0.8), and (1.5 ± 0.2) μmol/L in hemagglutination assay, cytopathic effect test, and quantitative RT-PCR assay, respectively.
Conclusion:
Arbidol has low cytotoxicity and high anti-virus activity and can effectively trigger the activities of interferon and immune response, and therefore can be a valuable anti-influenza virus drug.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP131707238	Arbidol hydrochloride		131707-23-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: